Modeling Cell Movement and Chemotaxis Using Pseudopod-Based Feedback
نویسندگان
چکیده
منابع مشابه
Modeling Cell Movement and Chemotaxis Using Pseudopod-Based Feedback
A computational framework is presented for the simulation of eukaryotic cell migration and chemotaxis. An empirical pattern formation model, based on a system of non-linear reaction-diffusion equations, is approximated on an evolving cell boundary using an Arbitrary Lagrangian Eulerian surface finite element method (ALE-SFEM). The solution state is used to drive a mechanical model of the protru...
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Chemotaxis is one of the most fascinating processes in cell biology. Shallow gradients of chemoattractant direct the movement of cells, and an intricate network of signalling pathways somehow instructs the movement apparatus to induce pseudopods in the direction of these gradients. Exciting new experiments have approached chemotaxis from the perspective of the extending pseudopod. These recent ...
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Many eukaryotic cells regulate their mobility by external cues. Genetic studies have identified >100 components that participate in chemotaxis, which hinders the identification of the conceptual framework of how cells sense and respond to shallow chemical gradients. The activation of Ras occurs during basal locomotion and is an essential connector between receptor and cytoskeleton during chemot...
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ژورنال
عنوان ژورنال: SIAM Journal on Scientific Computing
سال: 2011
ISSN: 1064-8275,1095-7197
DOI: 10.1137/100788938